吳嘉霖老師
學習與記憶研究室
期刊論文
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Lee WP, Chiang MH, Chang LY, Lee JY, Tsai YL, Chiu TH, Chiang HC, Fu TF, Wu T, Wu CL*. (2020) Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila. PLOS Genetics, 16(8): e1008963. (*corresponding author).
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Lien WY, Chen YT, Li YJ, Wu JK, Huang KL, Lin JR, Lin SC, Hou CC, Wang HD, Wu CL, Huang SY, Chan CC*. (2020). Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27. Aging Cell, e13179 doi 10.1111/acel.13179.
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Sneapati B, Tsao CH, Juan YA, Chiu TH, Wu CL, Waddell S, Lin S*. (2019, Oct). A neural mechanism for deprivation state-specific expression of relevant memories in Drosophila. Nature Neuroscience, 22. 2029-2039.
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Chen YR, Li YH, Hsieh TC, Wang CM, Cheng KC, Wang L, Lin TY, Cheung CHA, Wu CL, Chiang H* (2019, Jun). Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity. Aging Cell, doi: 10.1111/acel.12989.
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Shyu WH, Lee WP, Chiang MH, Chang CC, Fu TF, Chiang HC, Wu T, Wu CL* (2019). Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila. PLOS Genetics, doi: 10.1371/journal.pgen.1008153. (*corresponding author).
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Lien HM, Wu HY, Hung CL, Chen CJ, Wu CL, Chen KW, Huang CL, Chang SJ, Chen CC, Lin HJ*, Lai CH* (2019). Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori. Scientific Reports, 9:4205/doi:10.1038/s41598-019-40735-y.
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Chen YA, Tzeng D TW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH*, Lai CH* (2018). Antrocin sensitizes prostate cancer cells to radiotherapy through inhibiting PI3K/AKT and MAPK signaling pathways. Cancers, 11: 34; doi:10.3390/cancer11010034.
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Wu CL*, Chang CC, Wu JK, Chiang MH, Yang CH, Chiang HC (2018). Mushroom body glycolysis is required for olfactory memory in Drosophila. Neurobiology of Learning and Memory, 150: 13-19. (*corresponding author).
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Chi KC, Tsai WC, Wu CL, Lin TY*, Hueng DY* (2018). An adult Drosophila glioma model for studying pathometabolic pathways of gliomagenesis. Molecular Neurobiology, doi: 10.1007/s12035-018-1392-2.
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Chen YA, Shih HW, Lin YC, Hsu HY, Wu TF, Tsai CH, Wu CL, Wu HY, Hsieh JT, Tang CH, Lai CH* (2018). Simvastatin sensitizes radioresistant prostate cancer cells by compromising DNA double-strand break repair. Frontiers in Pharmacology, 9: 600.
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Ji XR, Cheng KC, Chen YR, Lin TY, Cheung CHA, Wu CL, Chiang HC* (2018). Dysfunction of different cellular degeneration pathways contributes to specific β-amyloid42-induced pathologies. FASEB Journal, 32(3): 1375-1387.
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Shyu WH, Chiu TH, Chiang MH, Cheng YC, Tsai YL, Fu TF, Wu T, Wu CL* (2017). Neural circuits for long-term water-reward memory processing in thirsty Drosophila. Nature Communications, 8: 15230; doi: 10.1038/ncomms15230. (*corresponding author).
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Yang CN, Wu MF, Liu CC, Jung WH, Chang YC, Lee WP, Shiao YJ, Wu CL, Liou HH, Lin SK, Chan CC* (2017) Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia. Human Molecular Genetics, 26(20): 3909-3921.
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Chen SL, Chen YH, Wang CC, Yu YW, Tsai YC, Hsu HW, Wu CL, Wang PY, Chen LC, Lan TH*, Fu TF* (2017). Active and passive sexual roles that arise in Drosophila male-male courtship are modulated by dopamine levels in PPL2ab neurons. Scientific Reports, 7:44595/doi:10.1038/srep44595.
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Yang CH, Shih MF M, Chang CC, Chiang MH, Shih HW, Tsai YL, Chiang AS, Fu TF, Wu CL* (2016). Additive expression of consolidated memory through Drosophila mushroom body subsets. PLOS Genetics, 12(5): e1006061. (*corresponding author).
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Wu CL*, Fu TF, Chiang MH, Chang YW, Her JL, Wu T (2016). Magnetoreception regulates male courtship activity in Drosophila. PLOS One, 11(5): e0155942 (*corresponding author).
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Shih HW#, Wu CL#*, Chang SW, Liu TH, Lai SY, Fu TF, Fu CC, Chiang AS* (2015). Parallel circuits control temperature preference in Drosophila during ageing. Nature Communications, 6: 7775; doi: 10.1038/ncomms8775. (#co-first authors, *co-corresponding authors).
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Kuo SY#, Wu CL#, Hsieh MY, Lin CT, Wen RK, Chen LC, Chen YH, Yu YW, Wang HD, Su YJ, Lin CJ, Yang CY, Guan HY, Wang PY, Lan TH*, Fu TF* (2015). PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine. Nature Communications, 6: 7490; doi: 10.1038/ncomms8490. (#co-first authors).
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Wu CL*, Fu TF, Chou YY, Yeh SR (2015). A single pair of neurons modulates egg-laying decisions in Drosophila. PLoS One, 10(3): e0121335. (*corresponding author).
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Wu CL, Shih MF M, Lee PT, Chiang AS* (2013). An octopamine-mushroom body circuit modulates the formation of anesthesia-resistant memory in Drosophila. Current Biology, 23: 2346-2354.
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Wu TH, Lu YN, Chuang CL, Wu CL, Chiang AS, Krantz DE, Chang HY*. (2013). Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. ACTA NEUROPATHOLOGICA, doi: 10.1007/s00401-013-1105-x.
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Kuo SY, Tu CH, Hsu YT, Wang HD, Wen RK, Lin CT, Wu CL, Huang YT, Huang GS, Lan TH, Fu TF* (2012). A hormone receptor-based transactivator bridges different binary systems to precisely control spatial-temporal gene expression in Drosophila. PLOS One, 7(12): e50855.
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Chen CC, Wu JK, Lin HW, Pai TP, Fu TF, Wu CL, Tully T, Chiang AS* (2012). Visualizing long-term memory formation in two neurons of Drosophila brain. Science, 335: 678-685.
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Wu CL, Shih MF M, Lai J SY, Yang HT, Turner CG, Chen L, Chiang AS* (2011). Heterotypic gap junctions between two neurons in the Drosophila brain are critical for memory. Current Biology, 21: 848-854.
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Chang YC, Hung WZ, Chang YC, Chang HC, Wu CL, Chiang AS, Jackson GR, Sang TK* (2011). Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model. PLOS Genetics, 7(2): e1001288.
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Wu CL, Chiang AS* (2008). Genes and circuits for olfactory-associated long-term memory in Drosophila. Journal of Neurogenetics, 22: 257-284.
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Wu CL, Xia S, Fu TF, Wang H, Chen YH, Leong D, Chiang AS*, Tully T* (2007). Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body. Nature Neuroscience, 10(12): 1578-1586.
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Xia S, Miyashita T, Fu TF, Lin WY, Wu CL, Pyzocha L, Lin IR, Saitoe M, Tully T, Chiang AS* (2005). NMDA receptors mediate olfactory learning and memory in Drosophila. Current Biology, 15: 603-615.
研討會論文
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Wu CL, Invited speaker. 2019 Asia-Pacific Drosophila Neurobiology Conference. January 16th-20th 2019, Taipei, Taiwan. Electrical synapses in Kenyon cells are critical for Drosophila olfactory memory.
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Wu CL, Invited speaker. The 13th Across the Taiwan Strait Symposium on Cell Biology. July 18th-22th 2018, Xining, China. Parallel brain circuits regulate long- and short-term memories in fruit fly.
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Wu CL, Invited speaker. EMBO Workshop on Neural Development. March 2nd-6rd 2018, Taipei, Taiwan. Water reward memory in Drosophila.
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Wu CL, Invited speaker. NPAS Symposium on Drosophila Neurobiology. July 26th 2017, Taipei, Taiwan. Water reward long-term memory in Drosophila.
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Wu CL, Invited speaker. The 16th Society of Chinese Bioscientists in America (SCBA) International Symposium; June 29 –July 3, 2017. Hangzhou, China. Synaptic Plasticity.
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Wu CL, Invited speaker. NCTS 2017 Challenges in Neuroscience. April 14, 2017, Hsinchu, Taiwan. Neural circuits for water reward long-term memory in Drosophila.
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Wu CL, Invited speaker. The 23th symposium on recent advances in cellular and Molecular Biology; Feb. 4-6, 2015. Kenting, Taiwan. Novel Technology: Brain circuits for consolidated memory in Drosophila.
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Wu CL, Invited speaker. SFN Neuroscience 2013; Nov. 9-13, 2013. San Diego, USA. Electrical coupling and microcircuits: Network operation and plasticity.
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Wu CL, Invited speaker. The 14th SCBA International Symposium; July. 18-22, 2013. Xi’an, China. The fly brain: Circuits and behavior.
專書
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Shih MFM, Wu CL* (2017, May) Network functions and Plasticity—Gap Junction Underlying Labile Memory. ELSEVIER (*corresponding author)
主持研究計畫
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調控果蠅水獎勵長期記憶形成之大腦神經機制。
(補助單位:科技部; 執行期間:2017/8/1~2020/7/31)
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果蠅水獎勵式記憶之神經網路探討。
(補助單位:科技部; 執行期間:2015/8/1~2017/7/31)
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果蠅大腦固化型記憶之神經與分子機制。
(補助單位:科技部; 執行期間:2015/8/1~2016/7/31)
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果蠅腦內中期記憶相關之分子與神經網路探討。
(執行期間:2012/8/1~2015/7/31; 補助單位:科技部)
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微小動物行為即時監控生物球 --以果蠅為例(子計畫四):生物球刺激源模組整合開發與測試。
(補助單位:科技部; 執行期間:2012/8/1~2015/7/31)
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蕈狀體外源神經細胞之電性突觸及化學性突觸對果蠅記憶的影響。
(補助單位:科技部; 執行期間:2012/1/1~2012/12/31)